Multifaceted Roles of Alendronate, Statin & Metformin in Periodontitis: Exploring the Multifaceted Roles of Alendronate, Statins, and Metformin: A Therapeutic Perspective - Softcover

Rathod, Dr. Surekha; Koli, Dr. Shivani; Kolte, Dr. Abhay

 
9786208423582: Multifaceted Roles of Alendronate, Statin & Metformin in Periodontitis: Exploring the Multifaceted Roles of Alendronate, Statins, and Metformin: A Therapeutic Perspective
Softcover
ISBN 10: 6208423589 ISBN 13: 9786208423582
Publisher: LAP LAMBERT Academic Publishing, 2025

Synopsis

Metformin, alendronate, and statins have emerged as promising local drug delivery (LDD) agents in the management of chronic periodontitis. These drugs exhibit diverse pharmacological properties that enhance periodontal regeneration and inflammation resolution when used adjunctively with conventional mechanical therapy. Each drug targets critical aspects of periodontitis pathophysiology, including inflammation, oxidative stress, and alveolar bone loss, making them valuable tools in enhancing therapeutic outcomes.The application of metformin, alendronate, and statins as LDD agents shows significant potential in improving clinical, radiographic, and biochemical parameters in chronic periodontitis. While the preliminary findings are promising, the variability in drug concentrations, formulations, and delivery systems calls for further standardization and long-term clinical trials. These agents could serve as valuable adjuncts to scaling and root planing (SRP), offering targeted therapeutic benefits with minimal systemic side effects. Their incorporation into routine periodontal care holds the potential to improve patient outcomes and redefine periodontal therapy strategies.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2025
Language
English
ISBN 10 
6208423589
ISBN 13 
9786208423582
Binding
Paperback
Number of pages
68