Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis - Softcover

El-Banna, Mona

Softcover

ISBN 10: 6208420326 ISBN 13: 9786208420321

Publisher: LAP LAMBERT Academic Publishing, 2025

Synopsis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness, atrophy, fasciculations, and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking, swallowing, and breathing, with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g., TDP-43 and FUS mutations), cytoskeletal and axonal transport defects (e.g., PFN1, TUBA4A mutations), excitotoxicity, and oxidative stress. While incurable, treatments like Riluzole and Edaravone can modestly slow progression, and supportive care—such as non-invasive ventilation, feeding tubes, and physical therapy—helps manage symptoms. Emerging therapies, including gene and RNA-targeted approaches, hold promise for the future.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2025
• Language: English
• ISBN 10: 6208420326
• ISBN 13: 9786208420321
• Binding: Paperback
• Number of pages: 60