Arginase Enzyme in Iraqi Acromegaly Patients: Biochemical Insights: Examining Effects in Acromegaly Patients with and without Diabetes - Softcover

Malek, Fatima Kh.; Abbas, Salma A.; Abed, Baydaa A.

Softcover

ISBN 10: 6207461800 ISBN 13: 9786207461806

Publisher: LAP LAMBERT Academic Publishing, 2024

Synopsis

L-arginase (EC 3.5.3.1), the final enzyme in the urea cycle, is a binuclear Mn2+ metalloenzyme. The enzyme catalyzes a reaction involving the hydrolysis of L-arginine to L-ornithine and urea. Acromegaly (ACRO) is a rare and complex hormonal syndrome classified as a chronic disorder characterized by elevated growth hormone (GH) and, consequently, insulin-like growth factor-1 (IGF-1). This is commonly caused by a GH-secreting pituitary adenoma, leading to multisystem impacts. These impacts affect the osteoarticular system, muscles, brain, heart and blood vessels, respiratory and hematopoietic system, kidneys, liver and pancreas, thyroid, adipose tissue, and metabolic system. The objective of this study is to evaluate the levels of arginase activity, GH, IGF-1, glucose, lipid profile, and serum urea in ACRO patients with and without diabetes. Additionally, the study aims to explore the correlation between Arginase and GH, glucose, and lipid profile.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2024
• Language: English
• ISBN 10: 6207461800
• ISBN 13: 9786207461806
• Binding: Paperback
• Number of pages: 80