Synopsis
Naive B cells and somatically mutated memory cells are produced by a process involving cell proliferation accompanied by stringent cellular selection, so that only cells of the desired phenotype survive. In both processes there is positive selection, first of cells with an in frame VHDHJH rearrangement, which can thus express a p-chain in the pBCR; then of B cells expressing a complete antibody in a functional receptor complex, presumably through expression of the BCR; and finally of somatic mutants expressing high-affinity antibodies in their BCR in the germinal center reaction. Only in the last case do we know the ligand that drives the selection; at earlier stages, selection may be driven by ligands on cells in the environment or by cell-autonomous mechanisms. In all cases, however, unselected cells are rapidly lost from the system, presumably by apoptosis.
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Development of Memory - B Cells
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LAP LAMBERT Academic Publishing Jul 2020, 2020
ISBN 10: 6202680210
ISBN 13: 9786202680219
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Naive B cells and somatically mutated memory cells are produced by a process involving cell proliferation accompanied by stringent cellular selection, so that only cells of the desired phenotype survive. In both processes there is positive selection, first of cells with an in frame VHDHJH rearrangement, which can thus express a p-chain in the pBCR; then of B cells expressing a complete antibody in a functional receptor complex, presumably through expression of the BCR; and finally of somatic mutants expressing high-affinity antibodies in their BCR in the germinal center reaction. Only in the last case do we know the ligand that drives the selection; at earlier stages, selection may be driven by ligands on cells in the environment or by cell-autonomous mechanisms. In all cases, however, unselected cells are rapidly lost from the system, presumably by apoptosis. 60 pp. Englisch. Seller Inventory # 9786202680219
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Development of Memory - B Cells
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LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6202680210
ISBN 13: 9786202680219
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: K K PrakashDr. Prakash K K is working as Associate Professor in the department of Biotechnology department in G M Institute of Technology, Davanagere, affiliated to VTU Belagavi and AICTE New Delhi. He obtained his Post Graduation fr. Seller Inventory # 494421910
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Development of Memory - B Cells
Published by
LAP LAMBERT Academic Publishing Jul 2020, 2020
ISBN 10: 6202680210
ISBN 13: 9786202680219
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Naive B cells and somatically mutated memory cells are produced by a process involving cell proliferation accompanied by stringent cellular selection, so that only cells of the desired phenotype survive. In both processes there is positive selection, first of cells with an in frame VHDHJH rearrangement, which can thus express a p-chain in the pBCR; then of B cells expressing a complete antibody in a functional receptor complex, presumably through expression of the BCR; and finally of somatic mutants expressing high-affinity antibodies in their BCR in the germinal center reaction. Only in the last case do we know the ligand that drives the selection; at earlier stages, selection may be driven by ligands on cells in the environment or by cell-autonomous mechanisms. In all cases, however, unselected cells are rapidly lost from the system, presumably by apoptosis.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 60 pp. Englisch. Seller Inventory # 9786202680219
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Development of Memory - B Cells
Published by
LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6202680210
ISBN 13: 9786202680219
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Naive B cells and somatically mutated memory cells are produced by a process involving cell proliferation accompanied by stringent cellular selection, so that only cells of the desired phenotype survive. In both processes there is positive selection, first of cells with an in frame VHDHJH rearrangement, which can thus express a p-chain in the pBCR; then of B cells expressing a complete antibody in a functional receptor complex, presumably through expression of the BCR; and finally of somatic mutants expressing high-affinity antibodies in their BCR in the germinal center reaction. Only in the last case do we know the ligand that drives the selection; at earlier stages, selection may be driven by ligands on cells in the environment or by cell-autonomous mechanisms. In all cases, however, unselected cells are rapidly lost from the system, presumably by apoptosis. Seller Inventory # 9786202680219