Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives: Aryl Propionic Acid Derivatives - Softcover

Kumar, Punet; Mishra, Arun K; KUMAR, ARVIND

Softcover

ISBN 10: 6202557079 ISBN 13: 9786202557078

Publisher: LAP LAMBERT Academic Publishing, 2020

Synopsis

The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2020
• Language: English
• ISBN 10: 6202557079
• ISBN 13: 9786202557078
• Binding: Paperback
• Number of pages: 104