Reliability and validity of Rhabdomayosarcoma histological diagnosis - Softcover

Mbwilo, Eva

 
9786202058643: Reliability and validity of Rhabdomayosarcoma histological diagnosis
Softcover
ISBN 10: 6202058641 ISBN 13: 9786202058643
Publisher: LAP LAMBERT Academic Publishing, 2019

Synopsis

Rhabdomyosarcomas (RMS) are soft tissue tumours of skeletal differentiation that are relatively common. They present a diagnostic challenge in histopathology laboratories where immunohistochemistry (IHC) staining is not routine. They tend to mimic many other tumours morphologically like small round blue cell tumour. Objectives: The aim of this study was to determine the reliability and validity of the morphological diagnosis of rhabdomyosarcoma using haematoxylin and eosin (H & E) with IHC as the reference standard in the Department of Pathology. This was a laboratory-based cross-sectional study to assess the reliability and validity of the morphological diagnosis of haematoxylin and eosin. All cases of rhabdomyosarcoma diagnosed using H&E during the study period from January 2000 to December 2012 in the Department of Pathology were sampled. The sample size in this study was 200 samples. Haematoxylin and eosin method has high sensitivity but low specificity with fairly high diagnostic accuracy. Therefore confirmation of all RMS cases diagnosed by H and E using IHC is necessary, as haematoxylin and eosin method has a high false positive rate.

"synopsis" may belong to another edition of this title.

Publisher
LAP LAMBERT Academic Publishing
Publication date
2019
Language
English
ISBN 10 
6202058641
ISBN 13 
9786202058643
Binding
Paperback
Number of pages
52