Synopsis
In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl buffer pH 1.2, acid phthalate buffer pH 4.0, phosphate buffer pH 6.8 and pH 7.4. In vitro reversion of Etodolac-glycine conjugate to Etodolac was done at different pH including colonic environment. In vitro reversion, showed prodrug to remain intact in all the other tested pH except colonic pH, where the colonic microfloral enzymes (amidase) hydrolyzed Etodolac-glycine conjugate amide linkage, releasing the free drug.
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Development of Colon Targetted Produg of Etodolac
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LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10: 6200224439
ISBN 13: 9786200224439
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl buffer pH 1.2, acid phthalate buffer pH 4.0, phosphate buffer pH 6.8 and pH 7.4. In vitro reversion of Etodolac-glycine conjugate to Etodolac was done at different pH including colonic environment. In vitro reversion, showed prodrug to remain intact in all the other tested pH except colonic pH, where the colonic microfloral enzymes (amidase) hydrolyzed Etodolac-glycine conjugate amide linkage, releasing the free drug. 76 pp. Englisch. Seller Inventory # 9786200224439
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Development of Colon Targetted Produg of Etodolac
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LAP LAMBERT Academic Publishing, 2021
ISBN 10: 6200224439
ISBN 13: 9786200224439
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Development of Colon Targetted Produg of Etodolac
Published by
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10: 6200224439
ISBN 13: 9786200224439
New
Taschenbuch
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Taschenbuch. Condition: Neu. Neuware -In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl buffer pH 1.2, acid phthalate buffer pH 4.0, phosphate buffer pH 6.8 and pH 7.4. In vitro reversion of Etodolac-glycine conjugate to Etodolac was done at different pH including colonic environment. In vitro reversion, showed prodrug to remain intact in all the other tested pH except colonic pH, where the colonic microfloral enzymes (amidase) hydrolyzed Etodolac-glycine conjugate amide linkage, releasing the free drug.Books on Demand GmbH, Überseering 33, 22297 Hamburg 76 pp. Englisch. Seller Inventory # 9786200224439
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Development of Colon Targetted Produg of Etodolac
Published by
LAP LAMBERT Academic Publishing, 2021
ISBN 10: 6200224439
ISBN 13: 9786200224439
New
Taschenbuch
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl buffer pH 1.2, acid phthalate buffer pH 4.0, phosphate buffer pH 6.8 and pH 7.4. In vitro reversion of Etodolac-glycine conjugate to Etodolac was done at different pH including colonic environment. In vitro reversion, showed prodrug to remain intact in all the other tested pH except colonic pH, where the colonic microfloral enzymes (amidase) hydrolyzed Etodolac-glycine conjugate amide linkage, releasing the free drug. Seller Inventory # 9786200224439
Seller Image
Development of Colon Targetted Produg of Etodolac
Published by
LAP LAMBERT Academic Publishing, 2021
ISBN 10: 6200224439
ISBN 13: 9786200224439
New
Taschenbuch
Seller: preigu, Osnabrück, Germany
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Taschenbuch. Condition: Neu. Development of Colon Targetted Produg of Etodolac | Gaurav Tiwari (u. a.) | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786200224439 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 120686940