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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones - Softcover
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We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Scholars' Press Dez 2022, 2022
ISBN 10: 6138976460
ISBN 13: 9786138976462
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. 164 pp. Englisch. Seller Inventory # 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. We evaluated the fluoroquinolones levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxic. Seller Inventory # 791057876
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model : Evaluation of Retinopathic Potential of Fluoroquinolones
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. Seller Inventory # 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
Published by
Scholars' Press Dez 2022, 2022
ISBN 10: 6138976460
ISBN 13: 9786138976462
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 164 pp. Englisch. Seller Inventory # 9786138976462