Drug Target Identification: G.bronchialis DSM 43247 (Strain 3410T) - Softcover

P.S, Srikumar; Karunakaran, Rohini; Srikumar, Afshan

Softcover

ISBN 10: 3848499576 ISBN 13: 9783848499571

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Gordonia bronchialis, a gram positive organism is known to cause infections in immunocompromised and immunocompentent hosts. It primarily causes lung, blood, wound infections and breast abscess. The bacterial strain DSM 43247 (Strain 3410T) was isolated from the sputum of a patient with pulmonary disease. The metabolic pathways involved, corresponding genes and its codon statistics were studied. The highly expressed gene was assumed to be the drug target based on the codon statistics value called codon adaptation index (CAI). From CAI results, key enzymes were selected by functional importance of pathway, enzyme role and frequency in various pathways. The 3D structure prediction analysis was carried out by homology modeling method. The active sites prediction was done by using Q site finder. Thus, the drug target identification by novel approach and its 3D structure prediction by homology modeling reveal more information and act as mode for the cure of Gordonia bronchialis DSM 43247 infections.

About this title

About the Author

Srikumar is a Senior Lecturer in the Faculty of Medicine, AIMST University, Malaysia. Though teaching Psychiatry is his passion, he has a keen interest in Bioinformatics and Forensic Science and has published papers on Bioinformatics among others.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848499576
• ISBN 13: 9783848499571
• Binding: Paperback
• Number of pages: 104