Solubility enhancement of diacerin using cyclodextrin: Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers - Softcover

Patrekar, Prasad; Dalvi, Vishal; Patil, Chandrakant

Softcover

ISBN 10: 3848486458 ISBN 13: 9783848486458

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with β-cyclodextrin (βCD) and hydroxyl propyl β-cyclodextrin (HP βCD).This study represents the formulation of inclusion complex with βCD and HP βCD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of βCD and HP βCD, especially with HP βCD. Complexation of Diacerein with hydrophilic carriers like βCD and HP βCD offers a major enhancement in drug solubility.

About this title

About the Author

Mr. Prasad Patrekar has successfully completed M. Pharm in Pharmaceutics.He has also completed post graduate degree in management studies. He is having a blend of experience in teaching and industry. He has also published several articles in reputed journals. Presently he is working as Principal at Adarsh Institute of Pharmacy.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848486458
• ISBN 13: 9783848486458
• Binding: Paperback
• Number of pages: 84