Unique Antibody Engineering Using Phage Display Technology: Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-α and Chicken Lysozyme - Softcover
Synopsis
The absolute target of molecular engineers has been to minimize the size of the antigen binding protein without compromising its functional affinity. Smaller fragments like Fabs, Fvs and single domain antibody fragments (also called dAbs) derived from the conventional bivalent IgG antibodies have been met with limited success due to problems in solubility, low expression yields in bacteria, instability and purification difficulties. The discovery of functional heavy chain antibodies devoid of light chains in camelid sera (Hamers-Casterman et al., 1993) revolutionized development of platforms from which the variable domains (VHHs) regarded as the smallest naturally intact antigen binding domains are derived from with significantly high affinities, comparable to those of Fvs. The camelid derived VHHs have several advantages such as; their small size facilitating their use in tumor imaging and therapy apart from being perfect targeting agents of toxic molecules to specific tissue due to ability to penetrate deep into tissues and bioclearence. This book highlights the methodology for isolation camel phage displayed single domain antibodies against murine TNF-α and chicken lysozyme.
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About the Author
Dr. Bernard Marasa is currently a Molecular Biologist at Catholic University of America (CUA) in Washington, DC. He is a leading expert in RNA Interference,Antibody engineering, Phage Display and HIV- vaccine Immunogen design. Dr. Marasa has a PhD in Molecular Medicine from University of Maryland, Baltimore and M.Sc from Vrije Universiteit Brussels
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Unique Antibody Engineering Using Phage Display Technology Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF and Chicken Lysozyme
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LAP LAMBERT Academic Publishing, 2012
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ISBN 13: 9783848441167
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Unique Antibody Engineering Using Phage Display Technology Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF and Chicken Lysozyme
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ISBN 13: 9783848441167
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Unique Antibody Engineering Using Phage Display Technology: Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-? and Chicken Lysozyme
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Unique Antibody Engineering Using Phage Display Technology: Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-� and Chicken Lysozyme
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Unique Antibody Engineering Using Phage Display Technology
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ISBN 13: 9783848441167
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The absolute target of molecular engineers has been to minimize the size of the antigen binding protein without compromising its functional affinity. Smaller fragments like Fabs, Fvs and single domain antibody fragments (also called dAbs) derived from the conventional bivalent IgG antibodies have been met with limited success due to problems in solubility, low expression yields in bacteria, instability and purification difficulties. The discovery of functional heavy chain antibodies devoid of light chains in camelid sera (Hamers-Casterman et al., 1993) revolutionized development of platforms from which the variable domains (VHHs) regarded as the smallest naturally intact antigen binding domains are derived from with significantly high affinities, comparable to those of Fvs. The camelid derived VHHs have several advantages such as; their small size facilitating their use in tumor imaging and therapy apart from being perfect targeting agents of toxic molecules to specific tissue due to ability to penetrate deep into tissues and bioclearence. This book highlights the methodology for isolation camel phage displayed single domain antibodies against murine TNF- and chicken lysozyme. 104 pp. Englisch. Seller Inventory # 9783848441167
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Unique Antibody Engineering Using Phage Display Technology
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Marasa Bernard S.Dr. Bernard Marasa is currently a Molecular Biologist at Catholic University of America (CUA) in Washington, DC. He is a leading expert in RNA Interference,Antibody engineering, Phage Display and HIV- vaccine Immunog. Seller Inventory # 5522413
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Unique Antibody Engineering Using Phage Display Technology
Published by
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ISBN 10: 3848441160
ISBN 13: 9783848441167
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The absolute target of molecular engineers has been to minimize the size of the antigen binding protein without compromising its functional affinity. Smaller fragments like Fabs, Fvs and single domain antibody fragments (also called dAbs) derived from the conventional bivalent IgG antibodies have been met with limited success due to problems in solubility, low expression yields in bacteria, instability and purification difficulties. The discovery of functional heavy chain antibodies devoid of light chains in camelid sera (Hamers-Casterman et al., 1993) revolutionized development of platforms from which the variable domains (VHHs) regarded as the smallest naturally intact antigen binding domains are derived from with significantly high affinities, comparable to those of Fvs. The camelid derived VHHs have several advantages such as; their small size facilitating their use in tumor imaging and therapy apart from being perfect targeting agents of toxic molecules to specific tissue due to ability to penetrate deep into tissues and bioclearence. This book highlights the methodology for isolation camel phage displayed single domain antibodies against murine TNF-¿ and chicken lysozyme.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 104 pp. Englisch. Seller Inventory # 9783848441167
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Unique Antibody Engineering Using Phage Display Technology : Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-¿ and Chicken Lysozyme
Published by
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ISBN 10: 3848441160
ISBN 13: 9783848441167
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The absolute target of molecular engineers has been to minimize the size of the antigen binding protein without compromising its functional affinity. Smaller fragments like Fabs, Fvs and single domain antibody fragments (also called dAbs) derived from the conventional bivalent IgG antibodies have been met with limited success due to problems in solubility, low expression yields in bacteria, instability and purification difficulties. The discovery of functional heavy chain antibodies devoid of light chains in camelid sera (Hamers-Casterman et al., 1993) revolutionized development of platforms from which the variable domains (VHHs) regarded as the smallest naturally intact antigen binding domains are derived from with significantly high affinities, comparable to those of Fvs. The camelid derived VHHs have several advantages such as; their small size facilitating their use in tumor imaging and therapy apart from being perfect targeting agents of toxic molecules to specific tissue due to ability to penetrate deep into tissues and bioclearence. This book highlights the methodology for isolation camel phage displayed single domain antibodies against murine TNF- and chicken lysozyme. Seller Inventory # 9783848441167
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Unique Antibody Engineering Using Phage Display Technology | Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-¿ and Chicken Lysozyme
Published by
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ISBN 10: 3848441160
ISBN 13: 9783848441167
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Taschenbuch. Condition: Neu. Unique Antibody Engineering Using Phage Display Technology | Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-¿ and Chicken Lysozyme | Bernard S. Marasa | Taschenbuch | 104 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783848441167 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu. Seller Inventory # 106411730
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Unique Antibody Engineering Using Phage Display Technology: Isolation of Camel Phage Displayed Functional Single Domain Antibody Fragments Against Mouse TNF-a and Chicken Lysozyme
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3848441160
ISBN 13: 9783848441167
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