Haemodynamic Optimization in Dopamine resistant Septic Shock: A comparison of phenylephrine and norepinephrine - Softcover

Jain, Gaurav; Singh, Dinesh

Softcover

ISBN 10: 3848435659 ISBN 13: 9783848435654

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

We performed a randomized, prospective, controlled trial in 54 patients, to compare norepinephrine and phenylephrine in the management of dopamine resistant septic shock. Patients were randomly allocated to receive either norepinephrine or phenylephrine infusion titrated to achieve a predefined haemodynamic and tissue perfusion targets for continuous 6 hrs as per protocol of our study. All the parameters were recorded every 30 min and increment in dose of studied drug was done in the specified dose range if targets were not achieved. Data from pulmonary arterial and hepatic vein catheterization, thermodilution catheter, blood gas analysis, blood lactate levels, invasive blood pressure, and oxygen transport variables were compared with baseline values after achieving the targets of therapy. No difference was observed in any of the investigated parameters except for statistically significant reduction of heart rate (HR) and increase in stroke volume index (SVI) by phenylephrine. We concluded that both drugs are comparable in reversing hemodynamic and metabolic abnormalities of sepsis patients, with an additional benefit of decrease in HR and improvement in SVI by phenylephrine.

About this title

About the Author

Dr. Gaurav Jain, having attained MD degree in Anaesthesia from CSMMU (Lucknow) and a PDCC degree in critical care from BHU (Varanasi), currently holds the position of Assistant Professor in the Department of Anaesthesia, TMU (Moradabad). His research interests include: ICU care, difficult airway management, regional anaesthesia and back pain.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• ISBN 10: 3848435659
• ISBN 13: 9783848435654
• Binding: Paperback
• Language: English
• Number of pages: 108