PPARγ gene polymorphisms and Infertility: Study of the relation between PPARγ gene polymorphisms and PPARγ protein level in human granoloza cells with ART success - Softcover

Nouri, Mohammad; Sahmani, Mahdi; Dolatkhah, Homayun

Softcover

ISBN 10: 3848423529 ISBN 13: 9783848423521

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Infertility is one of the prevalent disorders among communities, especially in women of childbearing age. Today, ART (assisted reproductive technology) such as IVF(in-vitro fertilization) and ICSI(Intra Cytoplasmic Sperm Injection) are used for treatment of infertile couples. Genetic factors have a crucial role in fertility and fetal development and the success of ART can be highly effected by these factors. In the present study, the relationship between HIS447His and Pro12Ala polymorphisms of PPARγ gene and also the PPARγ protein level with the number of oocyte and fertility rate in women candidate for IVF has been investigated. According of the results of this study two common polymorphisms in PPARγ gene may have an important role in-vitro fertilization and possibly rate. In addition no significant relation was found between PPARγ protein concentration in granoloza cell and the ART success rate.

About this title

About the Author

I am an associate-professor of Clinical Biochemistry in Faculty of Medicine, Tabriz University of Medical Sciences. I have certificate A.R.T. lab. technique, ICSI and IVF from Wife Hospital, Kiel University, Kiel, Germany and also Health Policy, Planning, and Economics from Nuffield Institute, Leeds, UK.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848423529
• ISBN 13: 9783848423521
• Binding: Paperback
• Number of pages: 92