Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors: An Overview: - Softcover

Elsori, Deena

Softcover

ISBN 10: 3848418134 ISBN 13: 9783848418138

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Activation of the NADPH oxidase enzyme complex results in the production of the oxygen free radical, superoxide anion (O2.-). Superoxide anion is critical for host defense against fungal and bacterial pathogens and efficient immune responses; however, uncontrolled monocyte-derived O2.- may contribute to chronic inflammation and tissue injury. We have previously identified several pathways that regulate the activity of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not yet been determined. This dissertation shows that pattern recognition receptors, namely Dectin-1, is essential for regulating NADPH oxidase activity in Zymosan-activated human monocytes. In addition this book focuses on Dectin-1 downstream signaling and complex formation with intracellular signaling proteins.

About this title

About the Author

Deena Elsori received her PhD in Regulatory and Cell Biology from Cleveland State University and the Cleveland Clinic in 2009. As an Assistant Professor of Biology at Abu Dhabi University (UAE),Deena is responsible for designing and teaching different biology courses.She is also the coordinator of the Public Health program at ADU.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848418134
• ISBN 13: 9783848418138
• Binding: Paperback
• Number of pages: 76