Characterizing Bacterial Secretion Systems Using Mass Spectrometry: Structural and Functional Characterization of Type III and Type VI Bacterial Secretion Systems - Softcover
Synopsis
Gram-negative bacteria have evolved an array of secretion systems for protein transport across their membranes. The ability to secrete a diverse set of proteins to their target of choice provides bacteria with a menacing tool for pathogenesis. This work aims to enhance our understanding of bacterial pathogenesis by characterizing key aspects of bacterial secretion systems using mass spectrometry. Chapter 1 provides a general introduction of protein secretion pathways in Gran-negative bacteria, with a special emphasis on type III and type VI secretion systems. Chapter 2 highlights chemical cross-linking and mass spectrometry (CXMS) as a technique for studying protein-protein interactions in large molecular complexes. Chapter 3 describes a novel pipeline for acquisition and analysis of CXMS data. In Chapter 4, key interactions between the basal components of type III secretion systems (T3SS) are identified, and used to create a model of the core structure of T3SS. In Chapter 5, secretome of T6SS in P. aeruginosa is profiled to identify three novel substrates of the system. Evidence of the involvement of one of these substrates in inter-bacterial interactions is presented.
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About the Author
Pragya Singh obtained her Ph.D degree in Medicinal Chemistry from University of Washington. Her doctoral research focused on structural characterization of protein complexes and identification of novel substrates of bacterial secretion systems, using mass spectrometry. She holds a post-doc position at Lawrence Berkeley National Lab, California.
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Characterizing Bacterial Secretion Systems Using Mass Spectrometry
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Gram-negative bacteria have evolved an array of secretion systems for protein transport across their membranes. The ability to secrete a diverse set of proteins to their target of choice provides bacteria with a menacing tool for pathogenesis. This work aims to enhance our understanding of bacterial pathogenesis by characterizing key aspects of bacterial secretion systems using mass spectrometry. Chapter 1 provides a general introduction of protein secretion pathways in Gran-negative bacteria, with a special emphasis on type III and type VI secretion systems. Chapter 2 highlights chemical cross-linking and mass spectrometry (CXMS) as a technique for studying protein-protein interactions in large molecular complexes. Chapter 3 describes a novel pipeline for acquisition and analysis of CXMS data. In Chapter 4, key interactions between the basal components of type III secretion systems (T3SS) are identified, and used to create a model of the core structure of T3SS. In Chapter 5, secretome of T6SS in P. aeruginosa is profiled to identify three novel substrates of the system. Evidence of the involvement of one of these substrates in inter-bacterial interactions is presented. 212 pp. Englisch. Seller Inventory # 9783847321194
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Characterizing Bacterial Secretion Systems Using Mass Spectrometry | Structural and Functional Characterization of Type III and Type VI Bacterial Secretion Systems
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Taschenbuch. Condition: Neu. Characterizing Bacterial Secretion Systems Using Mass Spectrometry | Structural and Functional Characterization of Type III and Type VI Bacterial Secretion Systems | Pragya Singh (u. a.) | Taschenbuch | 212 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783847321194 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Seller Inventory # 106420767
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Characterizing Bacterial Secretion Systems Using Mass Spectrometry
Published by
LAP LAMBERT Academic Publishing Jun 2012, 2012
ISBN 10: 3847321196
ISBN 13: 9783847321194
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Gram-negative bacteria have evolved an array of secretion systems for protein transport across their membranes. The ability to secrete a diverse set of proteins to their target of choice provides bacteria with a menacing tool for pathogenesis. This work aims to enhance our understanding of bacterial pathogenesis by characterizing key aspects of bacterial secretion systems using mass spectrometry. Chapter 1 provides a general introduction of protein secretion pathways in Gran-negative bacteria, with a special emphasis on type III and type VI secretion systems. Chapter 2 highlights chemical cross-linking and mass spectrometry (CXMS) as a technique for studying protein-protein interactions in large molecular complexes. Chapter 3 describes a novel pipeline for acquisition and analysis of CXMS data. In Chapter 4, key interactions between the basal components of type III secretion systems (T3SS) are identified, and used to create a model of the core structure of T3SS. In Chapter 5, secretome of T6SS in P. aeruginosa is profiled to identify three novel substrates of the system. Evidence of the involvement of one of these substrates in inter-bacterial interactions is presented.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 212 pp. Englisch. Seller Inventory # 9783847321194
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Characterizing Bacterial Secretion Systems Using Mass Spectrometry : Structural and Functional Characterization of Type III and Type VI Bacterial Secretion Systems
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ISBN 13: 9783847321194
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Gram-negative bacteria have evolved an array of secretion systems for protein transport across their membranes. The ability to secrete a diverse set of proteins to their target of choice provides bacteria with a menacing tool for pathogenesis. This work aims to enhance our understanding of bacterial pathogenesis by characterizing key aspects of bacterial secretion systems using mass spectrometry. Chapter 1 provides a general introduction of protein secretion pathways in Gran-negative bacteria, with a special emphasis on type III and type VI secretion systems. Chapter 2 highlights chemical cross-linking and mass spectrometry (CXMS) as a technique for studying protein-protein interactions in large molecular complexes. Chapter 3 describes a novel pipeline for acquisition and analysis of CXMS data. In Chapter 4, key interactions between the basal components of type III secretion systems (T3SS) are identified, and used to create a model of the core structure of T3SS. In Chapter 5, secretome of T6SS in P. aeruginosa is profiled to identify three novel substrates of the system. Evidence of the involvement of one of these substrates in inter-bacterial interactions is presented. Seller Inventory # 9783847321194
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Characterizing Bacterial Secretion Systems Using Mass Spectrometry: Structural and Functional Characterization of Type III and Type VI Bacterial Secretion Systems
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ISBN 13: 9783847321194
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