Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs - Softcover

Walsangikar, Sandeep D.; Bhatia, Neela M.; Bhatia, Manish S.

 
9783846551608: Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs
Softcover
ISBN 10: 3846551600 ISBN 13: 9783846551608
Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer’s disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach.

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About the Author

Mr. Walsangikar S. D. has completed his M. Pharmacy in Pharmaceutical Chemistry. He has published various research papers in international journals as author and contributed as co author in various research papers. He has excellant knowledge of synthetic chemistry. Currently he is working as Assistant Professor at GIPER Satara.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2012
Language
English
ISBN 10 
3846551600
ISBN 13 
9783846551608
Binding
Paperback
Number of pages
80