DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES: Ionotropic Gelation and Double Desolvation Technique - Softcover

Singh, Vandana; Chaudhary, Amrendra; Ahmed, Shamim

Softcover

ISBN 10: 3844393684 ISBN 13: 9783844393682

Publisher: LAP LAMBERT Academic Publishing, 2011

Synopsis

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

About this title

About the Author

Mrs. Vandana Singh graduated from Dr.K.N.M.I.P.E.R, Modinagar, and post graduated from Bundelkhand University, Jhansi. She is having 1 year of industrial and 4 years of teaching experience. Currently working as Senior Lecturer at Translam Institute of Pharmaceutical Education and Research, Meerut, India.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2011
• Language: English
• ISBN 10: 3844393684
• ISBN 13: 9783844393682
• Binding: Paperback
• Number of pages: 92