Modeling of Diffusion-reaction System in the Neuromuscular Junction: A Stable and Accurate Finite Difference Method - Softcover

Khaliq, Abdul; Jenkins, Frank

Softcover

ISBN 10: 3844391525 ISBN 13: 9783844391527

Publisher: LAP LAMBERT Academic Publishing, 2011

Synopsis

A new stable and accurate numerical method is used to solve the equations with Neumann boundaries in cylindrical coordinates. The simulation analysis agrees with experimental measurements of end-plate current and agrees well with the results of the conformational state of the acetylcholine receptor as a function of time and acetylcholine concentration of earlier investigations with a smaller error compared to experiments. An asymmetric emission of acetylcholine in the synaptic cleft and the subsequent effects on open receptor population is simulated. Sensitivity of the open receptor dynamics to the changes in the diffusion parameters and neuromuscular junction volume is investigated. The effects of anisotropic diffusion and non-symmetric emission of transmitter at the pre-synaptic membrane is simulated.

About this title

About the Author

Dr. Abdul Khaliq obtained his Ph.D. (2010) in engineering with concentration in micro and nano systems and a master’s degree in electrical engineering (2002) at Louisiana Tech University. He is working as a research engineer/computational scientist at Institute for Micromanufacturing at Louisiana Tech University.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2011
• Language: English
• ISBN 10: 3844391525
• ISBN 13: 9783844391527
• Binding: Paperback
• Number of pages: 108