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SYNTHESIS OF COMPOUNDS CONTAINING 9(10H)-ACRIDONE: SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS CONTAINING 9(10H)-ACRIDONE, AND STUDYING THEIR BIOLOGICAL ACTIVITY - Softcover

Hameed, Ayad; Yousif, Emad; Kreem, Ayad

 
9783844327861: SYNTHESIS OF COMPOUNDS CONTAINING 9(10H)-ACRIDONE: SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS CONTAINING 9(10H)-ACRIDONE, AND STUDYING THEIR BIOLOGICAL ACTIVITY

Synopsis

Acridone derivatives containing 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole rings are synthesized.Diphenylamine-2,4'-dicarboxylic acid [1] is obtained in a high yield by refluxing a mixture of 4-aminobenzoic acid and 2-chloro benzoic acid in the presence of catalytic amount of copper oxide. 9(10H)-Acridone-2-carboxylic acid [2] is synthesized in ring closure reaction by heating compound [1] in sulfuric acid followed by basic hydrolysis.Reaction of compound [2] with thiosemicarbazide in the presence of phosphorus oxychloride gave 2-[5-amino-1, 3, 4-thiadiazole-2-yl]-9(10H)-acridone

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About the Authors

Ayad Hameed, Emad Yousif and Ayad Kreem, Department of Chemistry, College of Science, AL-Nahrain University, Baghdad, Iraq. Jumat Salimon and Nadia Salih,School of Chemical Science and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia

Ayad Hameed, Emad Yousif and Ayad Kreem, Department of Chemistry, College of Science, AL-Nahrain University, Baghdad, Iraq. Jumat Salimon and Nadia Salih,School of Chemical Science and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia

Ayad Hameed, Emad Yousif and Ayad Kreem, Department of Chemistry, College of Science, AL-Nahrain University, Baghdad, Iraq. Jumat Salimon and Nadia Salih,School of Chemical Science and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia

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