Items related to GASTRORETENTIVE DRUG DELIVERY: Floating Matrix Tablets
Synopsis
The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulation.
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About the Author
Mr. J. Negi, has completed his post Graduation in Pharmaceutics specialization. He published research articles and abstracts in various journals and conferences.
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Search results for GASTRORETENTIVE DRUG DELIVERY: Floating Matrix Tablets
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Gastroretentive Drug Delivery
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
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Softcover
Seller: Books Puddle, New York, NY, U.S.A.
Seller rating 4 out of 5 stars
Condition: New. pp. 132. Seller Inventory # 26128858754
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GASTRORETENTIVE DRUG DELIVERY
Published by
LAP LAMBERT Academic Publishing Dez 2010, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
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Taschenbuch
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulation. 132 pp. Englisch. Seller Inventory # 9783843385268
Quantity: 2 available
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Gastroretentive Drug Delivery
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
New
Softcover
Seller: Majestic Books, Hounslow, United Kingdom
Seller rating 5 out of 5 stars
Condition: New. Print on Demand pp. 132 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. Seller Inventory # 131695965
Quantity: 4 available
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Gastroretentive Drug Delivery
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
New
Softcover
Seller: Biblios, Frankfurt am main, HESSE, Germany
Seller rating 5 out of 5 stars
Condition: New. PRINT ON DEMAND pp. 132. Seller Inventory # 18128858760
Quantity: 4 available
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GASTRORETENTIVE DRUG DELIVERY
Published by
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
New
Softcover
Seller: moluna, Greven, Germany
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Negi Jeetendra SinghMr. J. Negi, has completed his post Graduation in Pharmaceutics specialization. He published research articles and abstracts in various journals and conferences.Autor/Autorin: Thakur VinayMr. J. Negi,. Seller Inventory # 5468368
Quantity: Over 20 available
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GASTRORETENTIVE DRUG DELIVERY
Published by
LAP LAMBERT Academic Publishing Dez 2010, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Neuware -The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulation.Books on Demand GmbH, Überseering 33, 22297 Hamburg 132 pp. Englisch. Seller Inventory # 9783843385268
Quantity: 2 available
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GASTRORETENTIVE DRUG DELIVERY : Floating Matrix Tablets
Published by
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3843385262
ISBN 13: 9783843385268
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulation. Seller Inventory # 9783843385268
Quantity: 1 available