Modulation of protein-protein interactions: The role of short peptides in modulating protein-protein interactions in-vivo - Softcover

Dar, Altaf

 
9783843361781: Modulation of protein-protein interactions: The role of short peptides in modulating protein-protein interactions in-vivo

Synopsis

Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.

"synopsis" may belong to another edition of this title.

About the Author

Altaf A Dar is currently working on identifying biomarkers involved in melanoma progression and metastasis at CPMC, San Francisco, CA. Previously Dr. Dar worked on gastric cancer at Vanderbilt University, Nashville, TN. Dr. Dar earned his PhD from Friedrich Schiller University, Jena Germany, where he worked on protein-protein interactions.

"About this title" may belong to another edition of this title.