Fast Dissolving Films: A Novel Approch For Delivery Of Losartan Potassium - Softcover

Patel, Parth; Patel, Kinjal

Softcover

ISBN 10: 3838384334 ISBN 13: 9783838384337

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

The present work of this book aims to prepare fast dissolving films of Losartan Potassium with purpose of developing rapid onset of action, which is very convenient for administration without using water. The films were prepared by solvent casting method. The plasticizer concentration was selected on the basis of flexibility, tensile strength and stickiness of the film. In the present study polyethylene glycol was used as plasticizes. Fast dissolving films were evaluated for drug content and the drug loading capacity. The dissolution profile and folding endurance were found to be satisfactory. The disintegration time of formulation F3 film was lowest (30 sec), so they release drug faster than other formulations.A drug-excipient interaction was performed by DSC and FTIR; results were shown that there was no interaction between drug and excipients used. In vitro release mechanism was evaluated by subjecting the dissolution data to various kinetic models and the drug release was found to best fit theKorsemeyer-peppas model. Hence it is concluded that Losartan Potassium fast dissolving films are successfully developed and evaluated.

About this title

About the Author

Parth Patel,Masters In Pharmacy (Pharmaceutics):Kalol Institute Of Pharmacy,Gujarat Technological University,Gujarat

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3838384334
• ISBN 13: 9783838384337
• Binding: Paperback
• Number of pages: 120