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Function of beta cell and extracellular RNAs as potential biomarker: Defining beta cell function and elucidating extracellular RNAs as potential biomarker - Softcover
Synopsis
Diabetes is a chronic disorder of glucose metabolism and a major cause of premature mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line derived from MIN6, has been described as highly glucose-responsive. This study aimed to investigate the GSIS function, changes in gene expression and, subsequently, to develop possible experimental approaches to overcome this loss. Understanding the molecular basis for loss of GSIS may contribute to better culture conditions for islets in transplantation programmes; it may also add to our understanding of beta cell insensitivity to high blood glucose in Type 2 diabetes. In parallel, in an attempt to identify more reliable biomarkers for diabetes, we also investigated if extracellular mRNAs are reproducibly detectable in conditioned medium (CM) from a range of insulin-producing cell types and in serum specimens from Type 2 diabetes and controls.
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About the Author
Ph.D from Dublin City University, Currently working in School of Pharmacy & Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Ireland
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Function of beta cell and extracellular RNAs as potential biomarker
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LAP LAMBERT Academic Publishing Feb 2011, 2011
ISBN 10: 3838341449
ISBN 13: 9783838341446
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Diabetes is a chronic disorder of glucose metabolism and a major cause of premature mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line derived from MIN6, has been described as highly glucose-responsive. This study aimed to investigate the GSIS function, changes in gene expression and, subsequently, to develop possible experimental approaches to overcome this loss. Understanding the molecular basis for loss of GSIS may contribute to better culture conditions for islets in transplantation programmes; it may also add to our understanding of beta cell insensitivity to high blood glucose in Type 2 diabetes. In parallel, in an attempt to identify more reliable biomarkers for diabetes, we also investigated if extracellular mRNAs are reproducibly detectable in conditioned medium (CM) from a range of insulin-producing cell types and in serum specimens from Type 2 diabetes and controls. 388 pp. Englisch. Seller Inventory # 9783838341446
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Function of beta cell and extracellular RNAs as potential biomarker : Defining beta cell function and elucidating extracellular RNAs as potential biomarker
Published by
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3838341449
ISBN 13: 9783838341446
New
Taschenbuch
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Diabetes is a chronic disorder of glucose metabolism and a major cause of premature mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line derived from MIN6, has been described as highly glucose-responsive. This study aimed to investigate the GSIS function, changes in gene expression and, subsequently, to develop possible experimental approaches to overcome this loss. Understanding the molecular basis for loss of GSIS may contribute to better culture conditions for islets in transplantation programmes; it may also add to our understanding of beta cell insensitivity to high blood glucose in Type 2 diabetes. In parallel, in an attempt to identify more reliable biomarkers for diabetes, we also investigated if extracellular mRNAs are reproducibly detectable in conditioned medium (CM) from a range of insulin-producing cell types and in serum specimens from Type 2 diabetes and controls. Seller Inventory # 9783838341446
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Function of beta cell and extracellular RNAs as potential biomarker
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ISBN 13: 9783838341446
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Function of beta cell and extracellular RNAs as potential biomarker | Defining beta cell function and elucidating extracellular RNAs as potential biomarker
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LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3838341449
ISBN 13: 9783838341446
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Taschenbuch. Condition: Neu. Function of beta cell and extracellular RNAs as potential biomarker | Defining beta cell function and elucidating extracellular RNAs as potential biomarker | Sweta Rani (u. a.) | Taschenbuch | 388 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783838341446 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 101312690
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Function of beta cell and extracellular RNAs as potential biomarker
Published by
LAP LAMBERT Academic Publishing Feb 2011, 2011
ISBN 10: 3838341449
ISBN 13: 9783838341446
New
Taschenbuch
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Diabetes is a chronic disorder of glucose metabolism and a major cause of premature mortality. The potential use of replacement beta cells as therapy for diabetes requires an ability to culture such cells while maintaining their functional status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line derived from MIN6, has been described as highly glucose-responsive. This study aimed to investigate the GSIS function, changes in gene expression and, subsequently, to develop possible experimental approaches to overcome this loss. Understanding the molecular basis for loss of GSIS may contribute to better culture conditions for islets in transplantation programmes; it may also add to our understanding of beta cell insensitivity to high blood glucose in Type 2 diabetes. In parallel, in an attempt to identify more reliable biomarkers for diabetes, we also investigated if extracellular mRNAs are reproducibly detectable in conditioned medium (CM) from a range of insulin-producing cell types and in serum specimens from Type 2 diabetes and controls.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 388 pp. Englisch. Seller Inventory # 9783838341446
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Function of beta cell and extracellular RNAs as potential biomarker: Defining beta cell function and elucidating extracellular RNAs as potential biomarker
Published by
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3838341449
ISBN 13: 9783838341446
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