Since the last edition of this book was published, major developments in computer technology have affected both the practice of medicine and the methods of analyzing medical data. These advances make the focus on this revised edition - understanding many of the statistical methods that are used in modern medical studies - all the more important. Two new chapters have been added by the authors. One provides readers with an introduction to the analysis of longitudinal data. The other augments previous material concerning the design of clinical trials, exploring topics such as the use of surrogate markers, multiple outcomes, equivalence trials and the planning of efficacy-toxicity studies. In addition to providing new information and fine-tuning the rest of the book, the authors have reorganized the final six chapters so that the topics build, naturally, on each other. This latest edition is recommended both as an introduction to medical statistics and as a valuable tool in explaining the more complex statistical methods and techniques used today.
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Noteworthy advances have occurred in both the practice of medicine and biostatistical methods since the previous edition of this book was published. For example, physicians' acceptance of the importance of 'evidence-based medicine' is much more widespread now than it was in the mid-1990s. Even a casual reading of the current medical literature reveals that a basic grasp of statistical concepts and a passing appreciation for what statistical analysis can and cannot do is essential in order to understand and critically assess published reports concerning the frontiers of medical research. The fourth revised edition of this highly successful volume represents the most substantial revision of "Using and Understanding Medical Statistics" since the first edition was published more than 20 years ago. The authors have added five entirely new chapters on Poisson regression, the analysis of variance, meta-analysis, diagnostic tests and the subject of measurement agreement and reliability. In addition, there are sections describing new topics or exploring new examples in the chapters on the Kaplan-Meier estimate, the log-rank test, longitudinal studies, data analysis, clinical trials and epidemiological applications. The end result is an excellent introduction to medical statistics, as well as a valuable reference concerning many of the more complex statistical methods and techniques currently appearing in medical publications.
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