COX-2: A New Target for Cancer Prevention and Treatment: 37 (Progress in Tumor Research, 37) - Hardcover

Hardcover

ISBN 10: 380557536X ISBN 13: 9783805575362

Publisher: S Karger AG, 2003

Synopsis

Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.

Edition details

• Publisher: S Karger AG
• Publication date: 2003
• Language: English
• ISBN 10: 380557536X
• ISBN 13: 9783805575362
• Binding: Hardcover
• Number of pages: 292
• Editor: Dannenberg A.J., DuBois R.N.