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Synopsis
This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.
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From the Back Cover
The volume focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter discusses the biological rationale in great detail, including in vitro work and work in animal models, and where appropriate, results from clinical trials.
The book is written by an international authorship of experts in this field. It is of interest to rheumatologists, immunologists, internists, investigators in immunology and rheumatology as well as the pharmaceutical industry.
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New Therapeutic Targets in Rheumatoid Arthritis.
Seller: Universitätsbuchhandlung Herta Hold GmbH, Berlin, Germany
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21 ills., 5 in color. XII, 225 p. Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Stamped. Progress in Inflammation Research. Seller Inventory # 5664DB
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New Therapeutic Targets in Rheumatoid Arthritis
Seller: Buchpark, Trebbin, Germany
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Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar. Seller Inventory # 3940302/12
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New Therapeutic Targets in Rheumatoid Arthritis
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Basel Birkhäuser Basel Springer Mrz 2009, 2009
ISBN 10: 3764382376
ISBN 13: 9783764382377
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials. 228 pp. Englisch. Seller Inventory # 9783764382377
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New Therapeutic Targets in Rheumatoid Arthritis
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New Therapeutic Targets in Rheumatoid Arthritis
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New Therapeutic Targets in Rheumatoid Arthritis (Progress in Inflammation Research)
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New Therapeutic Targets in Rheumatoid Arthritis
Published by
Springer, Basel, Birkhäuser Basel, Birkhäuser, 2009
ISBN 10: 3764382376
ISBN 13: 9783764382377
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Hardcover
Seller: AHA-BUCH GmbH, Einbeck, Germany
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - During the past decades important breakthroughs have been made in the treatment of rheumatoid arthritis (RA). First, the implementation of low-dose methotrexate and other conventional disease-modifying anti-rheumatic drugs was introduced as an effective treatment. Second, it was recognized that early immunomodu- tory treatment is crucial for controlling the disease and its long-term destructive effects more effectively. Parallel advances in research on the pathogenesis of RA and cytokine biology converged in identifying tumor necrosis factor (TNF) as a key factor in inflammation and matrix destruction. The concept arose that elevated TNF concentrations at the sites of inflammation were driving disease pathology, and the removal of excess TNF from sites of inflammation became a therapeutic goal. Clearly, TNF blockade has revolutionized the treatment of RA, as well as other immune-mediated inflammatory diseases. Anti-TNF treatment results in cli- cal benefit in a significant proportion of the patients, and it has provided proof of concept for the principle of targeted therapy. Despite the impressive disease-modifying effects of the TNF blockers, not all patients respond, and patients who exhibited an initial response may lose response due to the development of anti-drug antibodies (human anti-chimeric antibodies and human anti-human antibodies, respectively) and perhaps as a result of escape mechanisms related to the disease process. In fact, the majority of the patients still have disease activity in at least one or two actively inflamed joints. Seller Inventory # 9783764382377
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New Therapeutic Targets in Rheumatoid Arthritis (Progress in Inflammation Research)
Seller: California Books, Miami, FL, U.S.A.
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NEW THERAPEUTIC TARGETS IN RHEUMATOID ARTHRITIS (Progress in Inflammation Research)
Seller: Books Puddle, Woodside, NY, U.S.A.
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Condition: New. pp. xii + 225 2009th edition. Seller Inventory # 26463665
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New Therapeutic Targets in Rheumatoid Arthritis
Seller: moluna, Greven, Germany
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Condition: New. Focuses on therapeutic targets that have recently been registered or are currently under development.Each chapter discusses the biological rationale in great detail including results from clinical trials.Written by an international aut. Seller Inventory # 5279800
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