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Prostaglandins and Control of Vascular Smooth Cell Proliferation: v. 48 (Agents and Actions, Supplements) - Hardcover
Synopsis
Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth- modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.
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Synopsis
Based on an International Conference held in Vienna, 1996, this volume contains contributions on several aspects of vascular smooth muscle function, phenotype expression and regulation of proliferation of vascular smooth muscle cell by prostaglandis or thromboxane.
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Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation
Published by
Birkhauser, Switzerland, 1997
ISBN 10: 3764356898
ISBN 13: 9783764356897
Used
Hardcover
Seller: The Book Exchange, Macclesfield, CHESH, United Kingdom
Seller rating 4 out of 5 stars
Hardcover. Condition: Fine. 3764356898. Pharmaceutical company library hardcover, with minimal wear. Lending record shows this book has never been borrowed. 130 pages, index, illustrated with charts, tables and diagrams. Based on an International Conference held in Vienna, contains contributions on aspects of vascular smooth muscle function, phenotype expression and regulation of proliferation of vascular smooth muscle by prostaglandins or thromboxane. Sections include: Regulation of differentiation/maturation; Novel indices of oxidant stress; Roles of Vasodilatory prostoglandins; Role of Thromboxane A2 in mitogenesis; Antimitotic actions; Prostacyclin and nitric oxide related gene transfer in preventing arterial thrombosis. Contents as new. Book. Seller Inventory # 025219
Quantity: 1 available
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Prostaglandins And Control Of Vascular Smooth Muscle Cell Proliferation
Published by
Birkhauser Verlag, Basel, Boston, Berlin, 1997
ISBN 10: 3764356898
ISBN 13: 9783764356897
Used
Hardcover
Seller: PsychoBabel & Skoob Books, Didcot, United Kingdom
Seller rating 5 out of 5 stars
Hardcover. Condition: Good. Dust Jacket Condition: No Dust Jacket. No dust jacket. Hardcover. Agents and Actions Supplements Vol. 48. Former owner's name is penned on front endpaper. Upper leading corners of boards are dented and rather bent; upper rear leading corner has minor fabric loss. Spine ends are a little creased. Pages are rather sunned around edges. Binding is sound and pages are tight throughout. Contents are clear. AF. Used. Seller Inventory # 281483
Quantity: 1 available