Prostaglandins and Control of Vascular Smooth Cell Proliferation: v. 48 (Agents and Actions, Supplements) - Hardcover

Hardcover

ISBN 10: 3764356898 ISBN 13: 9783764356897

Publisher: Birkhauser Verlag AG, 1997

Synopsis

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth- modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

About this title

Synopsis

Based on an International Conference held in Vienna, 1996, this volume contains contributions on several aspects of vascular smooth muscle function, phenotype expression and regulation of proliferation of vascular smooth muscle cell by prostaglandis or thromboxane.

Edition details

• Publisher: Birkhauser Verlag AG
• Publication date: 1997
• Language: English
• ISBN 10: 3764356898
• ISBN 13: 9783764356897
• Binding: Hardcover
• Number of pages: 136
• Editor: Schror Karsten, Nev P.