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The Carbonic Anhydrases: New Horizons: 90 (Experientia Supplementum, 90) - Hardcover

 
9783764356705: The Carbonic Anhydrases: New Horizons: 90 (Experientia Supplementum, 90)

Synopsis

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

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Product Description

The carbonic anhydrases play important roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This text examines the role of carbonic anhydrases. The enzyme is present in three known gene families: the a-CAs (animals and algae) of which seven isozymes have been characterized; the b-CAs (plants and bacteria); and the recently discovered g-CAs (archaebacteria). In addition to their clinical and applied physiological importance, the carbonic anhydrases have become accepted as a model for the study of evolution of gene families and also used as model systems in site-directed mutagenesis in structure/function relationships, protein folding and transgenic and gene target analysis.

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