Recent concepts in host modulation therapy - Softcover

Vijay Thakkar, Priya; Beldar, Amol; Raghavan, Merekhna

Softcover

ISBN 10: 3659922951 ISBN 13: 9783659922954

Publisher: LAP LAMBERT Academic Publishing, 2016

Synopsis

Periodontal diseases are initiated by Gram-negative tooth associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast- related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins,cytokines and other osteoclast-derived enzymes. This book focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth. Furthermore various therapeutic approaches that target MMPs, cytokines,cathepsins and other osteoclast-derived enzymes , such as MMP inhibitors, chemically modified tetracyclines, subantimicrobial formulations of tetracycline analogues, and various new agents such as periodontal vaccines, Probiotics, Grape seed proanthocyanidins, Cranberry fraction, omega 3 fatty acid, locally administered HMT agents are discussed. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted.

About this title

About the Author

Dr Amol Beldar is Reader and PG guide in Department of Periodontics and Implantology at MGV’s KBH Dental College and Hospital. He has many national and international scientific articles to his credit. Dr Priya Vijay Thakkar and Dr Merekhna Raghavan are post graduate student in department of periodontics and Implantology at MGV’s KBH Dental College.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2016
• Language: English
• ISBN 10: 3659922951
• ISBN 13: 9783659922954
• Binding: Paperback
• Number of pages: 84