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Synopsis
Graphene, a two dimensional carbon-based nanomaterial, have attracted great research interest and are of paramount importance in numerous fields including biomedical areas. With rapid surge in research and development activities on carbon nanomaterials, risks associated with them are reasons for serious concern among scientific community. Any material injected intravenously is bound to encounter and possibly interact with blood cells, particularly platelets which are known to be highly responsive and RBCs, cells present in abundance in blood, much before the nanomaterial reaches target tissues. We evaluated the effect of graphene oxide (GO) on platelet activity and found GO can potentially activate platelets. GO-induced platelet activation could be attributed to release of intracellular free calcium from cytosolic stores and activation of non-receptor protein tyrosine kinases of Src family in platelets. Contrasting the observation with GO,amine modified graphene (G-NH2) not shown any stimulatory action towards platelets. Thus, G-NH2 can be a safer alternative to GO, with potential biomedical applications in areas like imaging, sensing, drug delivery as well as photothermal therapy.
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About the Author
Dr.Singh did Masters and PhD degree in Biotechnology from BHU,India and is engaged in forefront research in Nanobiotechnology at MNNIT Allahabad, India. His research credentials are globally acknowledged and is also a recipient of prestigious INSA Medal for Young Scientist and NASI-Young Scientist Platinum Jubilee Award for the year 2014 and 2015.
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Exploration of interface between graphene sheets and thrombus biology
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LAP LAMBERT Academic Publishing Mai 2016, 2016
ISBN 10: 3659890685
ISBN 13: 9783659890680
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Graphene, a two dimensional carbon-based nanomaterial, have attracted great research interest and are of paramount importance in numerous fields including biomedical areas. With rapid surge in research and development activities on carbon nanomaterials, risks associated with them are reasons for serious concern among scientific community. Any material injected intravenously is bound to encounter and possibly interact with blood cells, particularly platelets which are known to be highly responsive and RBCs, cells present in abundance in blood, much before the nanomaterial reaches target tissues. We evaluated the effect of graphene oxide (GO) on platelet activity and found GO can potentially activate platelets. GO-induced platelet activation could be attributed to release of intracellular free calcium from cytosolic stores and activation of non-receptor protein tyrosine kinases of Src family in platelets. Contrasting the observation with GO,amine modified graphene (G-NH2) not shown any stimulatory action towards platelets. Thus, G-NH2 can be a safer alternative to GO, with potential biomedical applications in areas like imaging, sensing, drug delivery as well as photothermal therapy. 116 pp. Englisch. Seller Inventory # 9783659890680
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Exploration of interface between graphene sheets and thrombus biology
Published by
LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659890685
ISBN 13: 9783659890680
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Graphene, a two dimensional carbon-based nanomaterial, have attracted great research interest and are of paramount importance in numerous fields including biomedical areas. With rapid surge in research and development activities on carbon nanomaterials, risks associated with them are reasons for serious concern among scientific community. Any material injected intravenously is bound to encounter and possibly interact with blood cells, particularly platelets which are known to be highly responsive and RBCs, cells present in abundance in blood, much before the nanomaterial reaches target tissues. We evaluated the effect of graphene oxide (GO) on platelet activity and found GO can potentially activate platelets. GO-induced platelet activation could be attributed to release of intracellular free calcium from cytosolic stores and activation of non-receptor protein tyrosine kinases of Src family in platelets. Contrasting the observation with GO,amine modified graphene (G-NH2) not shown any stimulatory action towards platelets. Thus, G-NH2 can be a safer alternative to GO, with potential biomedical applications in areas like imaging, sensing, drug delivery as well as photothermal therapy. Seller Inventory # 9783659890680
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Exploration of interface between graphene sheets and thrombus biology
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LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659890685
ISBN 13: 9783659890680
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh Sunil KumarDr.Singh did Masters and PhD degree in Biotechnology from BHU,India and is engaged in forefront research in Nanobiotechnology at MNNIT Allahabad, India. His research credentials are globally acknowledged and is also . Seller Inventory # 158877541
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Exploration of interface between graphene sheets and thrombus biology
Published by
LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659890685
ISBN 13: 9783659890680
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Paperback. Condition: Brand New. 116 pages. 8.66x5.91x0.27 inches. In Stock. Seller Inventory # 3659890685
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Exploration of interface between graphene sheets and thrombus biology
Published by
LAP LAMBERT Academic Publishing Mai 2016, 2016
ISBN 10: 3659890685
ISBN 13: 9783659890680
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Graphene, a two dimensional carbon-based nanomaterial, have attracted great research interest and are of paramount importance in numerous fields including biomedical areas. With rapid surge in research and development activities on carbon nanomaterials, risks associated with them are reasons for serious concern among scientific community. Any material injected intravenously is bound to encounter and possibly interact with blood cells, particularly platelets which are known to be highly responsive and RBCs, cells present in abundance in blood, much before the nanomaterial reaches target tissues. We evaluated the effect of graphene oxide (GO) on platelet activity and found GO can potentially activate platelets. GO-induced platelet activation could be attributed to release of intracellular free calcium from cytosolic stores and activation of non-receptor protein tyrosine kinases of Src family in platelets. Contrasting the observation with GO,amine modified graphene (G-NH2) not shown any stimulatory action towards platelets. Thus, G-NH2 can be a safer alternative to GO, with potential biomedical applications in areas like imaging, sensing, drug delivery as well as photothermal therapy.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch. Seller Inventory # 9783659890680