Synopsis
Quan Zou introduces a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method for both dichotomous trait and quantitative trait locus (QTL). The approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method which requires the parental mating information. This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions, based on which, three linkage tests: the proportion, the mean test, and the LOD score test are proposed. Monte Carlo simulation studies have been conducted in order to evaluate the performance of the tests for different relative relationships. Finally, the distribution of disease affectional status is extended to the two-locus model: Quan Zou demonstrates that the ITO matrices at the two loci are decomposed under independence assumption, so that the affectional status distribution given IBD sharing at two loci can be determined through each contributing locus.
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About the Author
Quan Zou is a HHS Consultant at United Health Group since 2015. Previously, Quan worked as a scientist at University of Nevada, Reno and completed a PhD in Statistics at George Washington University, DC.
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The Generalized Relative Pairs IBD Distribution:
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ISBN 13: 9783659818486
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Quan Zou introduces a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method for both dichotomous trait and quantitative trait locus (QTL). The approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method which requires the parental mating information. This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions, based on which, three linkage tests: the proportion, the mean test, and the LOD score test are proposed. Monte Carlo simulation studies have been conducted in order to evaluate the performance of the tests for different relative relationships. Finally, the distribution of disease affectional status is extended to the two-locus model: Quan Zou demonstrates that the ITO matrices at the two loci are decomposed under independence assumption, so that the affectional status distribution given IBD sharing at two loci can be determined through each contributing locus. 104 pp. Englisch. Seller Inventory # 9783659818486
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The Generalized Relative Pairs IBD Distribution:
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Zou QuanQuan Zou is a HHS Consultant at United Health Group since 2015. Previously, Quan worked as a scientist at University of Nevada, Reno and completed a PhD in Statistics at George Washington University, DC.Quan Zou introduce. Seller Inventory # 158248089
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The Generalized Relative Pairs IBD Distribution:
Published by
LAP LAMBERT Academic Publishing Jan 2016, 2016
ISBN 10: 3659818488
ISBN 13: 9783659818486
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Quan Zou introduces a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method for both dichotomous trait and quantitative trait locus (QTL). The approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method which requires the parental mating information. This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions, based on which, three linkage tests: the proportion, the mean test, and the LOD score test are proposed. Monte Carlo simulation studies have been conducted in order to evaluate the performance of the tests for different relative relationships. Finally, the distribution of disease affectional status is extended to the two-locus model: Quan Zou demonstrates that the ITO matrices at the two loci are decomposed under independence assumption, so that the affectional status distribution given IBD sharing at two loci can be determined through each contributing locus.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 104 pp. Englisch. Seller Inventory # 9783659818486
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The Generalized Relative Pairs IBD Distribution: : Its Use in the Detection of Linkage
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Quan Zou introduces a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method for both dichotomous trait and quantitative trait locus (QTL). The approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method which requires the parental mating information. This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions, based on which, three linkage tests: the proportion, the mean test, and the LOD score test are proposed. Monte Carlo simulation studies have been conducted in order to evaluate the performance of the tests for different relative relationships. Finally, the distribution of disease affectional status is extended to the two-locus model: Quan Zou demonstrates that the ITO matrices at the two loci are decomposed under independence assumption, so that the affectional status distribution given IBD sharing at two loci can be determined through each contributing locus. Seller Inventory # 9783659818486
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The Generalized Relative Pairs IBD Distribution: | Its Use in the Detection of Linkage
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Taschenbuch. Condition: Neu. The Generalized Relative Pairs IBD Distribution: | Its Use in the Detection of Linkage | Quan Zou | Taschenbuch | 104 S. | Englisch | 2016 | LAP LAMBERT Academic Publishing | EAN 9783659818486 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 104013509
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The Generalized Relative Pairs IBD Distribution:: Its Use in the Detection of Linkage
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