Synthesis and characterization of nateglinide derivatives: Synthesis and characterization of nateglinide derivatives - Softcover

Sharma, Rajdeep; Ahsan, Mohamed Jawed; Siddiqui, I. H.

 
9783659769207: Synthesis and characterization of nateglinide derivatives: Synthesis and characterization of nateglinide derivatives
Softcover
ISBN 10: 3659769207 ISBN 13: 9783659769207
Publisher: LAP LAMBERT Academic Publishing, 2015

Synopsis

A series of seven nateglinide analogues were synthesized successfully using 4-isopropyl cyclohexyl carboxylic acid (trans acid) as starting material, react with thionyl chloride and formed trans-4-isopropyl cyclohexane carbonyl chloride (trans acid chloride) as an intermediate which further reacted with D-phenylalanine to yield nateglinide. The derivatives were synthesized by reacting nateglinide and ethylchloroformate, and formed an unstable mix anhydride compound, which further react with primary and secondary amines to yield the nateglinide derivatives. All these molecules were characterized spectroscopically by mass spectra, IR, 1H NMR.

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About the Author

Rajdeep Sharma, a student of Maharishi Arvind College of Pharmacy(MACP), Jaipur, India has completed his M. Pharmacy (PharmaceuticalChemistry) Project under the supervision of Dr. Mohamed Jawed Ahsan. Dr. Ahsan has published more than 40 articles in Journals of repute. Dr. I. H. Siddiqui is Senior Scientist in Cadila Pharmaceuticals, India

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2015
Language
English
ISBN 10 
3659769207
ISBN 13 
9783659769207
Binding
Paperback
Number of pages
96