Synopsis
Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.
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About the Author
Dr. Nanda Kumar Yellapu is a Bioinformatics Scientist at Biomedical Informatics Centre of Vector Control Research Centre (ICMR), Pondicherry, India. He obtained his Masters degree from SVIMS University and PhD from Sri Venkateswara University, Tirupati, India. His research focuses on the protein conformational studies and drug discovery strategies.
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Structure and Functional Correlations of Human Glucokinase
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LAP Lambert Academic Publishing Sep 2016, 2016
ISBN 10: 3659635537
ISBN 13: 9783659635533
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes. 172 pp. Englisch. Seller Inventory # 9783659635533
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Structure and Functional Correlations of Human Glucokinase
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Yellapu Nanda KumarDr. Nanda Kumar Yellapu is a Bioinformatics Scientist at Biomedical Informatics Centre of Vector Control Research Centre (ICMR), Pondicherry, India. He obtained his Masters degree from SVIMS University and PhD from. Seller Inventory # 159143207
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Structure and Functional Correlations of Human Glucokinase
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Structure and Functional Correlations of Human Glucokinase
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 172 pp. Englisch. Seller Inventory # 9783659635533
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Structure and Functional Correlations of Human Glucokinase
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ISBN 10: 3659635537
ISBN 13: 9783659635533
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Taschenbuch. Condition: Neu. Structure and Functional Correlations of Human Glucokinase | Nanda Kumar Yellapu (u. a.) | Taschenbuch | 172 S. | Englisch | 2016 | LAP LAMBERT Academic Publishing | EAN 9783659635533 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 103371972
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Structure and Functional Correlations of Human Glucokinase
Published by
LAP Lambert Academic Publishing, 2016
ISBN 10: 3659635537
ISBN 13: 9783659635533
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes. Seller Inventory # 9783659635533