Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies - Softcover
Synopsis
Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability.
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About the Author
Shantanu Bandyopadhyay, M.Pharm, has recently submitted his doctoral research to Panjab University, Chandigarh, India. He has contributed in 13 research and review publications, 1 book review, 4 book chapters and 36 poster presentations. He is currently member of editorial board of one journal and on the reviewer’s panel of 2 journals.
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe
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LAP LAMBERT Academic Publishing Jun 2013, 2013
ISBN 10: 3659404691
ISBN 13: 9783659404696
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability. 156 pp. Englisch. Seller Inventory # 9783659404696
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bandyopadhyay ShantanuShantanu Bandyopadhyay, M.Pharm, has recently submitted his doctoral research to Panjab University, Chandigarh, India. He has contributed in 13 research and review publications, 1 book review, 4 book chapters an. Seller Inventory # 5154090
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe
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ISBN 10: 3659404691
ISBN 13: 9783659404696
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 156 pp. Englisch. Seller Inventory # 9783659404696
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe | Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
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Taschenbuch. Condition: Neu. Formulation of Self Nano-Emulsifying Systems of Ezetimibe | Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies | Shantanu Bandyopadhyay (u. a.) | Taschenbuch | 156 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659404696 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Seller Inventory # 105906409
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Formulation of Self Nano-Emulsifying Systems of Ezetimibe : Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability. Seller Inventory # 9783659404696
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Formulation Of Self Nano-Emulsifying Systems Of Ezetimibe: Effect Of Lipidic Chain Length And Hlb Of Emulgents On In Vitro, In Situ Perfusion And In Vivo Pharmacodynamic Studies
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ISBN 13: 9783659404696
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