Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer - Softcover
Synopsis
Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU
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About the Author
Vipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under the Guidance of Dr. J. K. Patel.
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum
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LAP Lambert Academic Publishing Jan 2015, 2015
ISBN 10: 3659337536
ISBN 13: 9783659337536
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBUgrounded IBUhysical mixture Co-grinding mixture Co-grinding mixture of IBU and MGG. The bioavailability study of IBU:GG and IBU:MGG mixture were done using male Sprague-Dawley rats. Drug serum concentration was estimated using HPLC method. Cmax value of ibuprofen found in case of IBU:MGG was higher as compared to pure IBU:GG mixtures. About 49 % improvement in oral bioavailability of ibuprofen was resulted with IBU:MGG mixture. 92 pp. Englisch. Seller Inventory # 9783659337536
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum
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LAP LAMBERT Academic Publishing, 2013
ISBN 10: 3659337536
ISBN 13: 9783659337536
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jambukiya VipulVipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under th. Seller Inventory # 5149495
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum
Published by
LAP LAMBERT Academic Publishing Feb 2013, 2013
ISBN 10: 3659337536
ISBN 13: 9783659337536
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Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBUVDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 92 pp. Englisch. Seller Inventory # 9783659337536
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum : Enhancement of Bioavailability by Using Natural Polymer
Published by
LAP Lambert Academic Publishing, 2013
ISBN 10: 3659337536
ISBN 13: 9783659337536
New
Taschenbuch
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBUgrounded IBUhysical mixture Co-grinding mixture Co-grinding mixture of IBU and MGG. The bioavailability study of IBU:GG and IBU:MGG mixture were done using male Sprague-Dawley rats. Drug serum concentration was estimated using HPLC method. Cmax value of ibuprofen found in case of IBU:MGG was higher as compared to pure IBU:GG mixtures. About 49 % improvement in oral bioavailability of ibuprofen was resulted with IBU:MGG mixture. Seller Inventory # 9783659337536
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum | Enhancement of Bioavailability by Using Natural Polymer
Published by
LAP LAMBERT Academic Publishing, 2015
ISBN 10: 3659337536
ISBN 13: 9783659337536
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Taschenbuch. Condition: Neu. Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum | Enhancement of Bioavailability by Using Natural Polymer | Vipul Jambukiya (u. a.) | Taschenbuch | 92 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659337536 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 106075234
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Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer
Published by
LAP LAMBERT Academic Publishing, 2013
ISBN 10: 3659337536
ISBN 13: 9783659337536
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