Engineering Genetic Logic Gates: Design and Functional Assembly of Synthetic Biological Circuits - Softcover

Wang, Baojun

Softcover

ISBN 10: 3659274798 ISBN 13: 9783659274794

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Programming living cells with synthetic gene circuits to perform desired tasks has been a major theme in the growing field of synthetic biology. However, gene circuit engineering currently lacks the same predictability and reliability as seen in other mature engineering disciplines. This book introduces the design methodology for engineering novel modular and orthogonal genetic logic devices, and the predictable functional assembly of modular biological components into customisable biological circuits. Various genetic logic devices, including AND, NOT and NAND gates, were constructed in Escherichia coli bacteria to achieve customised cellular computing and sensing. An effective parts-based engineering approach is presented for assembling individual biological parts into functional circuits using engineered ‘in-context’ characterised modules aided by modelling. The book is a pioneering work in the field, and should be useful for engineers who would like to engineer synthetic biological systems for human desired purposes and for biologists who are interested in the design principles of natural biological circuits.

About this title

About the Author

Dr Baojun Wang obtained his PhD degree in Bioengineering at Imperial College London. His research centres on the design and engineering of synthetic biological devices and circuits for customised cellular computing and sensing. He is currently a Research Fellow at Imperial and works on building an interface between cellular and electronic systems.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659274798
• ISBN 13: 9783659274794
• Binding: Paperback
• Number of pages: 208