Items related to Fast Dissolving Tablets Of Chlorpromazine And Promethazine:...

Fast Dissolving Tablets Of Chlorpromazine And Promethazine: Fast Dissolving Tablets - Softcover

Ganesh Kumar, Gudas; Umamaheshwari, R.; Bhikshapathi, D.V.R.N

 
9783659232466: Fast Dissolving Tablets Of Chlorpromazine And Promethazine: Fast Dissolving Tablets
Softcover
ISBN 10: 3659232467 ISBN 13: 9783659232466
Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Chlorpromazine HCl and Promethazine HCl are potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Chlorpromazine HCl and Promethazine HCl was prepared and studied and the formulation F2 and S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate

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About the Author

Ganesh Kumar Gudas, M.Pharm (Ph.D) Assistant Professor, Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Siddipet (A.P)India. He has over 8 research publications to his credit in national and international journals. His research interest extends from Novel Drug Delivery Systems to Delivery Aspects of Biopharmaceuticals.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2012
Language
English
ISBN 10 
3659232467
ISBN 13 
9783659232466
Binding
Paperback
Number of pages
116