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Synopsis
Fast dissolving films have become popular as a new delivery system because they are easy to administer and sudden onset of drug action is possible as the films are taken through the sublingual route. In present study Zolmitriptan fast dissolving sublingual films were prepared which allow fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of drug action. The fast dissolving films were prepared by solvent casting method. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E5) and maltodextrin were used as film forming polymer due to their hydrophilic nature. Proposed combination provides acceptable dissolving criteria owing to HPMC E5 and better mechanical properties due to maltodextrin. Propylene glycol, citric acid, mannitol and mango flavour were used as a plasticizer, saliva stimulating agent, sweetener and flavouring agent respectively. Drug-excipients compatibility study was done using FT-IR spectroscopy. The prepared films were evaluated for thickness, weight variation, disintegration time, surface pH, folding endurance, drug content, in vitro dissolution, tensile strength and % elongation.
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
LAP LAMBERT Academic Publishing Mai 2014, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
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Taschenbuch
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fast dissolving films have become popular as a new delivery system because they are easy to administer and sudden onset of drug action is possible as the films are taken through the sublingual route. In present study Zolmitriptan fast dissolving sublingual films were prepared which allow fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of drug action. The fast dissolving films were prepared by solvent casting method. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E5) and maltodextrin were used as film forming polymer due to their hydrophilic nature. Proposed combination provides acceptable dissolving criteria owing to HPMC E5 and better mechanical properties due to maltodextrin. Propylene glycol, citric acid, mannitol and mango flavour were used as a plasticizer, saliva stimulating agent, sweetener and flavouring agent respectively. Drug-excipients compatibility study was done using FT-IR spectroscopy. The prepared films were evaluated for thickness, weight variation, disintegration time, surface pH, folding endurance, drug content, in vitro dissolution, tensile strength and % elongation. 116 pp. Englisch. Seller Inventory # 9783659223952
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
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Seller: Books Puddle, Woodside, NY, U.S.A.
Seller rating 4 out of 5 stars
Condition: New. pp. 116. Seller Inventory # 26128106491
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
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Seller: moluna, Greven, Germany
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Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dabhi KhushbuKhushbu Dabhi, Master of Pharmacy, Pharmaceutics. Studied M. Pharm., Pharmaceutics at K. B. Raval College of Pharmacy, Gandhinagar, Gujarat, India under Gujarat Technological University.Fast dissolving films have bec. Seller Inventory # 158591813
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
New
Softcover
Seller: Majestic Books, Hounslow, United Kingdom
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Condition: New. Print on Demand pp. 116 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. Seller Inventory # 131399716
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
New
Softcover
Seller: Biblios, Frankfurt am main, HESSE, Germany
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Condition: New. PRINT ON DEMAND pp. 116. Seller Inventory # 18128106481
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan : For Sublingual Use
Published by
LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
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Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Fast dissolving films have become popular as a new delivery system because they are easy to administer and sudden onset of drug action is possible as the films are taken through the sublingual route. In present study Zolmitriptan fast dissolving sublingual films were prepared which allow fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of drug action. The fast dissolving films were prepared by solvent casting method. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E5) and maltodextrin were used as film forming polymer due to their hydrophilic nature. Proposed combination provides acceptable dissolving criteria owing to HPMC E5 and better mechanical properties due to maltodextrin. Propylene glycol, citric acid, mannitol and mango flavour were used as a plasticizer, saliva stimulating agent, sweetener and flavouring agent respectively. Drug-excipients compatibility study was done using FT-IR spectroscopy. The prepared films were evaluated for thickness, weight variation, disintegration time, surface pH, folding endurance, drug content, in vitro dissolution, tensile strength and % elongation. Seller Inventory # 9783659223952
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan
Published by
LAP LAMBERT Academic Publishing Mai 2014, 2014
ISBN 10: 3659223956
ISBN 13: 9783659223952
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Fast dissolving films have become popular as a new delivery system because they are easy to administer and sudden onset of drug action is possible as the films are taken through the sublingual route. In present study Zolmitriptan fast dissolving sublingual films were prepared which allow fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of drug action. The fast dissolving films were prepared by solvent casting method. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E5) and maltodextrin were used as film forming polymer due to their hydrophilic nature. Proposed combination provides acceptable dissolving criteria owing to HPMC E5 and better mechanical properties due to maltodextrin. Propylene glycol, citric acid, mannitol and mango flavour were used as a plasticizer, saliva stimulating agent, sweetener and flavouring agent respectively. Drug-excipients compatibility study was done using FT-IR spectroscopy. The prepared films were evaluated for thickness, weight variation, disintegration time, surface pH, folding endurance, drug content, in vitro dissolution, tensile strength and % elongation.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch. Seller Inventory # 9783659223952
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Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan | For Sublingual Use
Published by
LAP LAMBERT Academic Publishing, 2018
ISBN 10: 3659223956
ISBN 13: 9783659223952
New
Taschenbuch
Seller: preigu, Osnabrück, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. Formulation and Evaluation of Fast Dissolving Film of Zolmitriptan | For Sublingual Use | Khushbu Dabhi (u. a.) | Taschenbuch | 116 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9783659223952 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 113177436