Formulation and Characterization of Aceclofenac Microsphere: Aceclofenac Microsphere - Softcover

Verma, Sofiya; Chaurasia, Sandhya; Asati, Ashok

Softcover

ISBN 10: 3659202320 ISBN 13: 9783659202322

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

The purpose of this research was to prepare and characterize Aceclofenac microsphere of guar gum polymer for the application of inflammation. Method: - The microsphere were prepared by using emulsification method using starch cross-linked agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. Result:-The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The stability study was conducted to conform the stability of prepared microsphere. In-vitro drug release study was performed in both simulated gastrointestinal fluid medium and rat cecal content of different pH. Conclusion:-The prepared Aceclofenac microsphere has the potential for delaying the release of drug.

About this title

About the Author

Sofiya Verma completed her M Pharmacy fromRajiv Gandhi Technical University Bhopal M.P.(India)Sofiya Verma having excellent academicsrecord. She is currently working as Asst. Professor at daksh institute of pharmaceutical science chhatarpur (M.P)

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659202320
• ISBN 13: 9783659202322
• Binding: Paperback
• Number of pages: 96