Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines: Chalcones, Pyrazolines, Isoxazolines, Isoxazoles derived from 3-Acetyl Quinolines: Antimicrobial and Cytotoxcity Studies - Softcover

Vijayakumar, V.; Sarveswari, S.

Softcover

ISBN 10: 3659202142 ISBN 13: 9783659202148

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-ones has been developed both by conventional and microwave assisted synthesis. The 3-acetyl quinolines were converted into chalcones which in turn converted to quinoline-3-yl pyrazolines and quinoline-3-yl isoxazolines and a few into 3-(2, 4-substitutedstyryl)isoxazolo[4,5-c]quinolin-4(5H)-ones. These compounds were explored for their anti-microbial and cyctotoxicity studies.

About this title

About the Author

Associate Professor in Organic Chemistry Division at VIT University, Vellore completed his Ph.D at Gandhigram University, Dindigul in Nitrogen Heterocycles. Focusing on the synthesis of various heterocycles and exploring their applications in medicinal field and published more than 130 articles in various international journals.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659202142
• ISBN 13: 9783659202148
• Binding: Paperback
• Number of pages: 248