Formulation and Characterization of Ranitidine Hydrochloride: Mucoadhesive Drug Delivery System - Softcover

Asati, Ashok; Verma, Sofiya; Chaurasia, Sandhya

 
9783659195679: Formulation and Characterization of Ranitidine Hydrochloride: Mucoadhesive Drug Delivery System
Softcover
ISBN 10: 3659195677 ISBN 13: 9783659195679
Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

prepare and evaluate mucoadhesive drug delivery system of Ranitidine hydrochloride tablet using hydrophilic polymers in order to reduce dose frequency to match the initial release of the drug with the conventional dosage form. The formulation was designed adopting optimization technique, which helps in setting up experiments in such a manner that the information is obtained as efficiently and precisely as possible. Initially, considering buoyancy as the main criteria, blank tablets were compressed for different formulae with various polymers HPMC K 15 M, HPMC K 100 M, Carbopol 934. The tablets were prepared by direct compression method and evaluated for Ranitdine content, in vitro release profile and buoyancy. The dissolution study was carried out in simulated gastric fluid using USP dissolution test apparatus employing paddle stirrer.. This indicates the suitability of the technique chosen for the present dosage form.

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About the Author

Ashok Asati completed his M Pharmacy from Singhania University Jhujhunu Rajasthan(India. Ashok Asati having excellent academics record. He is currently working as Asst. Professor at daksh institute of pharmaceutical science chhatarpur (M.P)

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2012
Language
English
ISBN 10 
3659195677
ISBN 13 
9783659195679
Binding
Paperback
Number of pages
140