Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP - Softcover

Kumar, Prasanth; Patel, Saumya; Pandya, Himanshu

Softcover

ISBN 10: 3659153125 ISBN 13: 9783659153129

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.

About this title

About the Author

S. Prasanth Kumar, a budding researcher in Department of Bioinformatics, Gujarat University. A recipient of DST INSPIRE fellowship from Ministry of Science and Technology, Government of India. He has been awarded Young Scientist Award twice. He's actively involved in research areas: molecular modeling, structural bioinformatics & sequence analysis.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659153125
• ISBN 13: 9783659153129
• Binding: Paperback
• Number of pages: 104