Microbial Biotransformation: L-DOPA Production: Using a novel fungus Penicillium jensenii - Softcover

Majumder, Devipriya; Raval, Komal; Vaswani, Pooja

Softcover

ISBN 10: 3659148180 ISBN 13: 9783659148187

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Biotransformation is the chemical modification(or alteration) of chemical compounds like amino acids, toxins, xenobiotics and drugs, brought about by an organism to produce bioactive molecules. Penicillium jensenii isolated from soil (rhizosphere zone) was found to be a potent tyrosinase producer. Tyrosinase is capable of bringing about biotransformation of a single amino acid tyrosine to L-DOPA (3, 4- dihydroxyphenylalanine) and alpha methyl DOPA. L-DOPA is converted into dopamine in the brain and body by the enzyme L-aromatic amino acid decarboxylase which is further responsible for all kinds of the voluntary movements of the body. The by-product Alpha methyl DOPA is equally commercially viable as an important anti hypertensive and psychoactive drug. Since L-DOPA remains the gold standard for the treatment of Parkinson’s disease, its production using microorganisms can hold a promising future for the small molecule pharmaceutical industry.

About this title

About the Author

Dr. (Mrs.) Devipriya Rabin Majumder (PhD Microbiology): HOD Microbiology, Abeda Inamdar Senior College, Pune.Ms. Komal Mukeshkumar Raval (M.Sc Microbiology): Research Assistant, Abeda Inamdar Senior College, Pune.Ms. Pooja Suresh Vaswani (M.Sc Microbiology): Research Assistant, Abeda Inamdar Senior College, Pune.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659148180
• ISBN 13: 9783659148187
• Binding: Paperback
• Number of pages: 80