Formulation and Characterization of Floating Tablet of Aceclofenac: Hydrodyanamically Balanced System - Softcover

Garg, Shiv Kumar; Gupta, Manish Kumar; Garg, Vinod Kumar

Softcover

ISBN 10: 3659136638 ISBN 13: 9783659136634

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

The present work focuses on the development of hydrodynamically balanced delivery system of Aceclofenac as a single-unit floating Tablet. Floating effervescent tablets were formulated by various materials like. HPMC, K4M, K 15M, psyllium husk, swelling agent as crospovidone and micro crystalline cellulose and gas generating agent like sodium bicarbonate and citric acid. Floating non effervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers. The prepared floating tablets were evaluated for various Parameter. The formulation was optimized on the basis of in vitro buoyancy and in vitro release By fitting the data into different models, we concluded that the mechanism of release of Aceclofenac from the floating tablet was anomalous diffusion transport and follows zero order kinetics, Stability studies revealed that formulations were stable when stored at different temperatures and the values were within permissible limits. X ray imaging studies results showed that tablet was float more than 8 h in gastric region of the Albino rabbits.

About this title

About the Author

Shiv Kumar Garg has completed his B.Pharma in 2004 from University of Rajasthan.then after in 2007 degree of M.pharma in Pharmaceutics awarded. he is also hold degree of M.B.A.in Human Resource and Recently he is Completed his PhD.in Pharmaceutical Sciences.Currently he is working as Assistant Professor in Sri Balaji College of Pharmacy,Jaipur(Raj)

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659136638
• ISBN 13: 9783659136634
• Binding: Paperback
• Number of pages: 164