Design & Developement of Floating Tablet of Tolperisone Hydrochloride: Gastroretentive drug delivery system - Softcover

Soni, Ravi; Patel, Mukesh; Patel, Natvarlal

Softcover

ISBN 10: 3659136069 ISBN 13: 9783659136061

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.

About this title

About the Author

Ravikumar P. SoniShri B.M. Shah College of Pharmaceutical Education and Research. Education:I received my B. Pharm from Vidya bharti trust college of pharmacy in 2010 (with English), my M. Pharm from Gujarat Technological university in 2012 (with English).

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659136069
• ISBN 13: 9783659136061
• Binding: Paperback
• Number of pages: 160