A Computational Model of Focal Ischemia: Methods in Computational Biology - Softcover

Revett, Kenneth

Softcover

ISBN 10: 3659122092 ISBN 13: 9783659122095

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Spreading depression, a phenomenon characterized by changes in a wide range of neurophysiological processes, was described by Aristides Leao in 1944. The defining feature is a relatively enduring depression in the spontaneous activity of the brain, recorded using standard unipolar electrodes. Further, the reduction in spontaneous activity spreads from the site of initiation across the surface of the cortex. The phenomenon was discovered while Leao was investigating the response of the rabbit cortex, under dial narcosis, to faradic stimulation. This monograph describes in significant detail how SD is initiated, which aspects of nervous tissue support its initiation and propagation, the dynamics of SD propagation, the potential involvement of subcortical structures in the initiation and spread of SD, and the influence of changes in vasculature on SD. The approach adopted in this work is based on a biologically realistic computational model of SD, designed to provide a simulation platform for investigating realistic scenarios. The resuls of this work indicate that computational modelling can provide useful information that is not easily acquired through alternative approaches.

About this title

About the Author

The author is a computational neuroscientist, specialising in modelling cortical spreading depression. This text provides a summary of the first biologically realistic model of SD. It is hoped that such efforts will demonstrate the utility of a computational modelling approach to solving long standing problems in neuroscience.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659122092
• ISBN 13: 9783659122095
• Binding: Paperback
• Number of pages: 208