Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems (BestMasters) - Softcover

Ondra, Thomas

Softcover

ISBN 10: 3658083433 ISBN 13: 9783658083434

Publisher: Springer Spektrum, 2014

Synopsis

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

About this title

About the Author

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

From the Back Cover

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Contents

• Introduction to Markov Decision Problems and Examples
• Finite and Infinite Horizon Markov Decision Problems
• Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
• Designing Response Adaptive Clinical Trials with Markov Decision Problems

Target Groups

• Researchers and students in the fields of mathematics and statistics
• Professionals in the pharmaceutical industry<

The Author

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

Edition details

• Publisher: Springer Spektrum
• Publication date: 2014
• Language: English
• ISBN 10: 3658083433
• ISBN 13: 9783658083434
• Binding: Paperback
• Number of pages: 117