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Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems (BestMasters) - Softcover

Book 4 of 91: BestMasters

Ondra, Thomas

 
9783658083434: Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems (BestMasters)
Softcover
ISBN 10: 3658083433 ISBN 13: 9783658083434
Publisher: Springer Spektrum, 2014

Synopsis

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

"synopsis" may belong to another edition of this title.

About the Author

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

From the Back Cover

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Contents

  • Introduction to Markov Decision Problems and Examples
  • Finite and Infinite Horizon Markov Decision Problems
  • Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
  • Designing Response Adaptive Clinical Trials with Markov Decision Problems

Target Groups

  • Researchers and students in the fields of mathematics and statistics
  • Professionals in the pharmaceutical industry<

The Author

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

"About this title" may belong to another edition of this title.

Publisher
Springer Spektrum
Publication date
2014
Language
English
ISBN 10 
3658083433
ISBN 13 
9783658083434
Binding
Paperback
Number of pages
117