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Synopsis
Peroxisomes - or microbodies - are organelles present in nearly all cells. Interest stems not only from their various biological and cell physiological roles but also because several genetic diseases are known with deficient peroxisomal functions. In response to several drugs or pesticides, peroxisomes start to proliferate. Due to this property they may also be used as toxicological indicators. Designed for use at the lab bench, this manual is ideal for everyone involved in peroxisome research or concerned with hepatotoxicity testing of new compounds.
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Peroxisomes (eng)
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Peroxisomes
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Discovered and first isolated in 1966 in C. De Duve'slaboratory, peroxisomes - organelles which are present innearly all eukaryotic cells - are still not fullyunderstood.More than 40 peroxisomal enzymes catalyzing a variety ofreactions have been characterized. Moreover, peroxisomes canbe regarded as toxicological indicators: several compounds,including hypolipemic drugs, plasticizers or pesticidestrigger their proliferation. This proliferation may leadto hepatocarcinogenesis in rodents.Interest in peroxisomes stems not only fromtheir biology,but also because there is a deficiency of peroxisomalfunctions in several genetic diseases. Some genes involvedin inborn errors of peroxisomal function have recently beenidentified.In this manual, based on a FEBS Advanced Course onperoxisomes, protocols on the following topics are describedin detail: Isolation and characterization of peroxisomes byultracentrifugationand immunoblotting; gene regulationstudied by mRNA isolation, hybridizationand DNA celltransfection; use of cell lines as peroxisome proliferatortargets; transformation with retrovirus; peroxisomes astoxicological markers; cytochrome P450 induction; drugdesign and computer analysis of ligand/receptor interactioninvolved in peroxisomal gene expression. 220 pp. Englisch. Seller Inventory # 9783642878091
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Peroxisomes
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Peroxisomes
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Peroxisomes
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Peroxisomes
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Peroxisomes - or microbodies - are organelles present in nearly all cells. Interest stems not only from their various biological and cell physiological roles but also because several genetic diseases are known with deficient peroxisomal functions. In respon. Seller Inventory # 5072933
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Peroxisomes (Springer Lab Manuals)
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Peroxisomes
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Peroxisomes - or microbodies - are organelles present in nearly all cells. Interest stems not only from their various biological and cell physiological roles but also because several genetic diseases are known with deficient peroxisomal functions. In response to several drugs or pesticides, peroxisomes start to proliferate. Due to this property they may also be used as toxicological indicators. Designed for use at the lab bench, this manual is ideal for everyone involved in peroxisome research or concerned with hepatotoxicity testing of new compounds.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 220 pp. Englisch. Seller Inventory # 9783642878091
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Peroxisomes
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ISBN 10: 3642878091
ISBN 13: 9783642878091
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Discovered and first isolated in 1966 in C. De Duve'slaboratory, peroxisomes - organelles which are present innearly all eukaryotic cells - are still not fullyunderstood.More than 40 peroxisomal enzymes catalyzing a variety ofreactions have been characterized. Moreover, peroxisomes canbe regarded as toxicological indicators: several compounds,including hypolipemic drugs, plasticizers or pesticidestrigger their proliferation. This proliferation may leadto hepatocarcinogenesis in rodents.Interest in peroxisomes stems not only fromtheir biology,but also because there is a deficiency of peroxisomalfunctions in several genetic diseases. Some genes involvedin inborn errors of peroxisomal function have recently beenidentified.In this manual, based on a FEBS Advanced Course onperoxisomes, protocols on the following topics are describedin detail: Isolation and characterization of peroxisomes byultracentrifugationand immunoblotting; gene regulationstudied by mRNA isolation, hybridizationand DNA celltransfection; use of cell lines as peroxisome proliferatortargets; transformation with retrovirus; peroxisomes astoxicological markers; cytochrome P450 induction; drugdesign and computer analysis of ligand/receptor interactioninvolved in peroxisomal gene expression. Seller Inventory # 9783642878091
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Peroxisomes
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Taschenbuch. Condition: Neu. Peroxisomes | Norbert Latruffe (u. a.) | Taschenbuch | Springer Lab Manuals | xvi | Englisch | 2013 | Springer | EAN 9783642878091 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 105718940