Selective Heat Sensitivity of Cancer Cells: 59 (Recent Results in Cancer Research, 59) - Softcover

Softcover

ISBN 10: 3642810829 ISBN 13: 9783642810824

Publisher: Springer, 2011

Synopsis

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio­ chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

Edition details

• Publisher: Springer
• Publication date: 2011
• Language: English
• ISBN 10: 3642810829
• ISBN 13: 9783642810824
• Binding: Paperback
• Number of pages: 204
• Editor: Rossi-Fanelli A., Cavaliere R., Mondovi B., Moricca G.