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Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the ... Topics in Microbiology and Immunology) - Softcover
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The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens.
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I : Transduction of Bcr Signals from the Cell Membrane to the Nucleus
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I
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Springer Berlin Heidelberg Okt 2012, 2012
ISBN 10: 3642630170
ISBN 13: 9783642630170
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical. 288 pp. Englisch. Seller Inventory # 9783642630170
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I : Transduction of BCR Signals from the Cell Membrane to the Nucleus
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Springer, Berlin, Springer Berlin Heidelberg, Springer, 2012
ISBN 10: 3642630170
ISBN 13: 9783642630170
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical. Seller Inventory # 9783642630170
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus (Current Topics in Microbiology and Immunology)
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Paperback. Condition: Brand New. 288 pages. 9.25x6.10x0.65 inches. In Stock. Seller Inventory # x-3642630170
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I | Transduction of BCR Signals from the Cell Membrane to the Nucleus
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Taschenbuch. Condition: Neu. Signal Transduction and the Coordination of B Lymphocyte Development and Function I | Transduction of BCR Signals from the Cell Membrane to the Nucleus | Louis B. Justement (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2012 | Springer | EAN 9783642630170 | Verantwortliche Person für die EU: Lauinger, Sonia, Sonia Lauinger, Lauinger Verlag, Heinrich-Köhler-Platz 8, 76187 Karlsruhe, mail[at]lauinger-verlag[dot]de | Anbieter: preigu. Seller Inventory # 105646104
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I
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Springer Berlin Heidelberg, 2012
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ISBN 13: 9783642630170
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I
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Signal Transduction and the Coordination of B Lymphocyte Development and Function I
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